The substitution of valine for glutamic acid in the sixth position of the p-chai

Question

The substitution of valine for glutamic acid in the sixth position of the p-chain of emoglobin produces sickle-cell anemia in the homozygote because (a) Co-operative binding of oxygen is lost because of the missing Glu-6 residue. As such the cell prevents oxygen from reaching the spleen, liver, kidneys, lungs, heart, or other organs causing a lot of damage. (b) The Apoprotein can no longer protect the heme iron from becoming oxidized owing to the presence of the hydrophobic Val-6 (c) The Val-6 variant loses solubility upon deoxygenation (d) The Val-6 variant tends to retain oxygen when the oxygen tension is low (e) The red cell is unable to sequester high enough concentrations of the Val-6 variant hemoglobin

Explanation / Answer

The substitution of valine for glutamic acid in the sixth position of the p-chai

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