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S-Adenosylmethionine (SAM or S-adoMet) serves as a methyl transfer molecule. The

ID: 264466 • Letter: S

Question

S-Adenosylmethionine (SAM or S-adoMet) serves as a methyl transfer molecule. The synthesis of SAM requires that the person have adequate supplies of 2 vitamins.

A) What 2 vitamins? Provide vitamin names. B) What kinds of molecules get methylated by SAM?   C) If the SAM synthetic pathway is impaired due to vitamin deficiency or an enzyme problem, homocysteine can accumulate in the blood. Its accumulation is associated with a very common medical condition (the leading cause of death in the US). What condition?

Explanation / Answer

S-Adenosylmethionine (SAM or S-adoMet) serves as a methyl transfer molecule. The

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S-Adenosyl-l-methionine (SAMe) is a dietary supplement used to treat depression.
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