For each of the situations described below: 1) Would the primary effect of the c

Question

For each of the situations described below: 1) Would the primary effect of the change occur during Transcription, RNA Processing, or Translation and 2) Describe the effect/consequence of the change

a) Deletion of the regulatory promoter

b) The following mutation (underlined) in the protein-coding region whose ORF is shown

5’- ATG-CCA-UAU-UAA-3’             5’- ATG-CCG-UAU-UAA-3’

          Met-Pro-Tyr

c) A mutation in the -10 promoter region that destroys the consensus sequence

d) A mutation in the branch point sequence

Explanation / Answer

B. 5’- ATG-CCA-UAU-UAA-3’5’- ATG-CCG-UAU-UAA-3’

As both CCA and CCG codes for proline

C. -10 component of promoter is essential to bind with transcription factors. If this -10 box is deleted, then transcription factors wont be able to bind and initiate transcription

D. branch point is required for RNA processing through splicing. So, A mutation in the branch point sequence will hamper splicing.

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