Protein misfolding can be an aspect of several different human disorders, includ

Question

Protein misfolding can be an aspect of several different human disorders, including cystic fibrosis, Alzheimer's disease, and atherosclerosis. Many times, the misfolded protein is a membrane protein. In fact, a type of diabetes insipidus results from a mutation in the G-protein-coupled vasopressin 2 receptor that prevents the protein from making it to the cell membrane! Describe how this type of receptor would normally get targeted to the membrane (from the beginning of translation) and then propose one mechanism by which the mutation could cause a lack of proper targeting.

Explanation / Answer

these mutations suggest the manner in which there occur a structural as well as functional relationship between the receptors. As a result of these mutations, there would be an elevation of the cAMP levels, which are present in an intracellular manner. As a result of these receptors, there would be stimulation of arginine vasopressin. G protein receptors lead to neohrogenic diabetes insipidus. There is. Misfolding in the arginine vasopressin receptors, which are present in the endoplasmic reticulum. As a result of this misfolding, receptors would not be able to reach the plasma membrane, and there would not be circulation of anti diuretic hormone. These, would also be referred to as x linked mutations. As the avp would be binding to the receptor, there would be activation of the G protein, resulting in activation of a cascade, that would be promoting the translocation of the water channels that have already been synthesised. This results in hamper of protein synthesis.

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