Which of the following statements about NADH and its effect on the citrate cycle

Question

Which of the following statements about NADH and its effect on the citrate cycle are true? Choose one or more: A. Increasing NADH concentrations will inhibit the citrate cycle. B. NADH will bind to the enzyme citrate synthase, and when there is significantly more NADH in the cell than NAD+, less citrate will be produced isocitrate dehydrogenase enzyme. activating the pyruvate dehydrogenase enzyme. C. Low concentrations of NADH will result in lower concentrations of ?-ketoglutarate due to inhibition of the -D. High concentrations of NADH will lead to an increased amount of acetyl-CoA being produced due to NADH

Explanation / Answer

First ques : Answer is option A

High amount of NADH inhibhit three enzymes/ complex mainly :

1- Isocitrate dehydrogenase

2- Alpha ketoglutarate dehydrogenase

3- Pyruvate dehydrogenase.

Low concentration of NADH will have not have any inhibhitory activity as such .

Second ques : Last option (D) Step 3 catalysed by isocitratd dehydrogenase.

NADH is produced in steps catalysed by :

Isocitrate dehydrogenase

Alpha ketoglutarate dehydrogenase

Malate dehydrogenase

3rd question : Option B

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