How will you determine whether the mouse genes have redundant functions? Drag th

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How will you determine whether the mouse genes have redundant functions?

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Reset Help homozygous for loss-of- function mutations in each gene heterozygous for loss-of function mutations in each gene lf Hoxa7 and Hoxb7 have one or more redundant functions, then a strain that is will have a more severe or different phenotype than the combinations of phenotypes of strains heterozygous for loss-of- function mutations in both genes Each single mutant would be created by performing gene knockouts and then the single mutant would be crossed to isolate double mutants. homozygous for loss-of- function mutations in both genes

Explanation / Answer

1) To determine whether a gene in mouse has a reduntant function. They can perform a knockout of the gene. If the mice has no phenotype due to the loss of that gene that means some other reduntant gene is making over for the same.

2) Homozygous for loss of function mutation in both the genes, Homozygous for loss of function mutation in each gene.

Since the genes are reduntant, loss of function of both gene will be more severe than loss of function of each gene. Because if one gene is lost, other can perform its function due to redundancy.

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