The complement system has been a target for the development of compounds that in
ID: 266432 • Letter: T
Question
The complement system has been a target for the development of compounds that interfere with the complement system as a means of treating chronic autoimmune diseases. One such compound is an inhibitor of the C5a receptor, a receptor expressed on macrophages, dendritic cells, and granulocytes. This C5a receptor inhibitor would function to prevent [complete the sentence and assess the resulting statements (79-82) as either factually correct (true) or incorrect (false)]:
79. the recruitment of macrophages and neutrophils to the sites of autoantibody binding.
80. cell lysis by the membrane attack complex.
81. cell uptake by phagocytic cells bearing complement receptors.
82. the binding of autoantibodies to activating Fc receptors.
Explanation / Answer
ANSWER
This C5a receptor inhibitor would function to prevent cell lysis by the membrane attack complex. As C5a complement system component is required to form Membrane attack complex (MAC) and this complex disturb the membrane of cells which allows easily pass of components in and out, leading to cell lysis.
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