c) Consider the metabolic pathway below in which Steroid A is converted to Stero

Question

c) Consider the metabolic pathway below in which Steroid A is converted to Steroid B and then into Steroid C. What are the structures of Steroid A and C. Fill in the missing groups using the given steroid skeleton. HINT: The enzyme in the second step is a hydrogenase specialized in the hydrogenation reaction with alkenes What type of enzyme is the one used in the first step (17B-HSD)? Starting with Steroid B with set stereochemistry, how many stereoisomers can be formed of Steroid C? explain briefly. OH 17B-HSD 5a-reductase NADH NADH NAD+ C NAD+ Steroid A Steroid B Steroid C

Explanation / Answer

Answer : 17beta HSD or 17beta hydroxysteroid dehydrogenase is an alcohol oxidoreductase

The given structure shows

Androstenedione----->17b Hsb---->steroid B=testosteron--->

5alpha reductase ------>DHT

Steroid A structure :

Steroid A is the same structure as Steroid B only change is the there is a Oxgen double bond =O in the carbon pentagon ring.

Steroid C structure :

In steroid C the the double bond O from the first hexagonal ring will be charged to single bind OH.

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