Some signaling pathways in the cell are chiefly based on inhibition rather than

Question

Some signaling pathways in the cell are chiefly based on inhibition rather than activation. For example, proteins that initiate programmed cell death by apoptosis are inhibited by anti-apoptotic proteins, which can in turn be inhibited by a group of pro-apoptotic proteins, and so on. Consider the following networks of inhibitory interactions, in which each protein is inactive if at least one of its inhibitors is active. In which pathway is the activation of either upstream protein (1 or 2) sufficient to inhibit apoptosis? C. Apoptosis 1 B. 2- Select one: a. A b. B c. D

Explanation / Answer

d. C

In this case the activation of either 1 or 2 is sufficient to initiate apoptosis. If 1 is active, it will inhibit antiapoptotic proteins, which will not be available to inhibit pro-apoptotic proteins. Thus, the cell will undergo apoptosis. If only B is active, it will initiate the apoptosis through a different pathway. So activation of either 1 or 2 is sufficient to initiate apoptosis. So the correct option ic C.

In case of A,B and D both 1 and 2 should be active to initiate apoptosis.

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