Help (9) An amino acid is coded for by a single codon. It is possible to carry o
ID: 266909 • Letter: H
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(9) An amino acid is coded for by a single codon. It is possible to carry ourent mutations; t five different SINGLE base pair substitutions in this single codon and derive fi five mutant alleles code for arginine, cysteine. glycine, leucine, and serimie a) What is the name for a mutation that changes a codon for one amin acid to a codon for another amino acid? (2 points) b) What was the original codon? What amino acid did it code for? 2 point c) Show how the original codon was mutated to a codon for arginine. Is this a transition or a transversion? (2 points) Is this a conservative or non-conservative substitution? Why? (1 bonus point) d) Show how the original cod transversion? (2 points Is this a transition or a on was mutated to code for cysteine. Is this a conservative or non-conservative substitution? Why? (1 bonus point) e) Show how the original codon was mutated to code for glycine. Is this a transition or a transversion? (2 points) Is this a conservative or non-conservative substitution? Why? (1 bonus point) Is this a transition or a f) Show how the original codon was mutated to code for leucine. transversion? (2 points) Is this a conservative or non-conservative substitution? Why? (1 bonus point) c) Show how the original codon was mutated to code for serine. Is this a transition or a transversion? (2 points) Is this a conservative or non-conservative substitution? Why? (1 bonus point) page 6 of 8Explanation / Answer
a. Missense mutation. It is observed in Sickle cell Anameia condition. Where in beta chain of Hemoglobin, Glutamate isis replaced by valine at 6th position
b. The original codon was 'UGG' that encodes Tryptophan
c. UGG encodes Tryptophan & CGG encodes Arginine. U to C mutation I. e. Transition. It is non conservative mutation in which the original amino acid and mutated amino acids have different properties
d. UGC encodes Cysteine. Here G to C conversion happened I. e. Transversion . Cysteine and Tryptophan are different amino acids. So it is Non conservative type of mutation
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