Part C How will you determine whether the mouse genes have redundant functions?

Question

Part C How will you determine whether the mouse genes have redundant functions? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not al terms will be used Reset Help homozygous for loss-of- function mutations in each gene If Hoxa7 and Hoxb7 have one or more redundant functions, then a strain that is will have a more severe or different phenotype than the combinations of phenotypes of strains Each single mutant would be created by performing gene knockouts and then the heterozygous for loss-of- function mutations in both genes single mutant would be crossed to isolate double mutants. heterozygous for loss-of- function mutations in each gene homozygous for loss-of function mutations in both genes

Explanation / Answer

Answer

To determine whether a gene has the redundant function or not, gene knockouts can be performed. If there exists any redundancy, then a loss of function for both gene would result in more severe phenotype since, if one gene is lost or remains nonfunctional, then another gene can perform its activity due to redundancy. Thus, the effect would be more severe for a loss-of-function for both genes than the loss of function in each gene.

Therefore, the first blank can be filled with homozygous for loss-of-function mutations in both genes and second blank can be filled with homozygous for loss-of-function mutations in in each gene.

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