Question 1 a) [10 marks / 10 minutes] 4 marks] What isitabout a mutant phenotype

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Question 1 a) [10 marks / 10 minutes] 4 marks] What isitabout a mutant phenotype that classifies the mutation as "temperature-sensitive? (i) How is this type of phenotype explained by protein behaviour? Would the following types of mutations most likely have: severe effects, mild effects, or no effect on protein function? Briefly explain your answers. Note that there may be more than one correct answer, but you need only to give one sensible answer and explain your reasoning. [6 marks] b) (i) A nonsense mutation occurring in sequences encoding amino acids near the carboxy terminus of the protein (ii) A missense mutation affecting the active site of the protein (iii) A frameshift mutation near the 5' end of the open reading frame

Explanation / Answer

Answer

a) 1 Temperature sensitive mutants are variants of genes that allow normal function of the organism at low temperatures, but altered function at higher temperatures.

2) At higher temperture, the structure and function will be altered of the protein

b) 1. mild effect as translation occurs in N-term to C-term

2. severe effect as missense mutation will replace amino acid from active site to some other amino acid

3. severe effect or mild, as depends upon the extent of the frame of the protein changed

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