QUESTION 21 A routine colonoscopy detects a small colorectal polyp on the colon

Question

QUESTION 21 A routine colonoscopy detects a small colorectal polyp on the colon wall that has not reached adenoma status. Which of the following genes would you most likely predict to be mutated at this stage? OA. p53 B. ras ? ???? D. antimetastasis gene QUESTION 22 Consider the Ras signal-transduction pathway. Suppose a mutation occurred in the gene that encodes MEK that renders it nonfunctional. Which of the following effects would you see in this situation? A. Ras would lose the ability to bind GTP and thus could no longer become activated, and the signal-transduction pathway would be halted at this step ? B Binding of the growth factor to the receptor would occur, but the receptor's conformational change that is needed for the pathway to go forward would not occur Inactive Ras would move into the nucleus and inactivate tur or suppressor ran sc p n actors, which could ultimately result i cancer D. MAP kinase would not be activated and thus could not move into the nucleus to activate transcription factors ( E. Activated Ras would no longer have the ability to activate Raf, and the signal transduction pathway would be halted at this step QUESTION 23 A drug is injected into a cell that inhibits the removal of phosphate groups from MPF. Which of the following would result? O A. The cell would not be able to progress through the G1/S checkpoirt B. Cyclin D could no longer be activated C. The cell would not be able to transition into mitosis. D. MPF would remain in its active state. E. Cyclin B levels would not be able to increase

Explanation / Answer

Q.21 (C) APC

Q.22 (D) MAP kinase would not activate so signal can not transport to nucleus

Q.23 (C) The cell would not able to transition into mitosis.

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