3. Imagine that you have engineered a set of genes (Jand 2), each encoding a pro

Question

3. Imagine that you have engineered a set of genes (Jand 2), each encoding a protein with one or two signal sequences that specify different compartments as shown here; Protein 1 M-6-P Protein 2 ER-import-...M-6-P | If the genes were expressed in a cell, predict the following; What will be the final destination of proteins (answer in one or two words only) Protein 1: Lysosome a. Protein2: Lysosome b. What type of coating(s) (COP 1, COP Il or Clatbrin) will be present on the vesicles when protein 2 is being transported?

Explanation / Answer

A. M-6-P is glycosylation made in golgi apparatus by which protein is transported to the lysosome.

B. For anterograde transport from ER to golgi COP II coating is found on the vesicles.

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