2. A mountain climber was trapped in a high mountain ravine for five days. Durin
ID: 267933 • Letter: 2
Question
2. A mountain climber was trapped in a high mountain ravine for five days. During that time she had no food but had plenty of water. She continued to try to find a way out so she was still moving most of the time she was trapped but was not able to find her way out. What is happening biochemically in this person in that fifth day without food? (20 pts) i. Hormones synthesized and released: Answer here) Expected signaling pathways for hormonal interaction with cells. Answer here) ii. Choose two of the following tissues and answer as completely as possible, putting the requested information in the appropriate places of the template i. Skeletal muscle Fuels being utilized and why these are the major fuels being utilized Answer here) Pathways which are being activated and pathways which are being inhibited. Explain why Answer here) Enzyme catalyzed reactions being stimulated and those being inhibited under these conditions. Explain (Answer here) ii.Adipse tissue Fuels being utilized and why these are the major fuels being utilized Answer here) Pathways which are being activated and pathways which are being inhibited. Explain why Answer here) Enzyme catalyzed reactions being stimulated and those being inhibited under these conditions. Explain (Answer here) ii.Liver tissue Fuels being utilized and why these are the major fuels being utilized Answer here) Pathways which are being activated and pathways which are being inhibited. Explain why Answer here)Explanation / Answer
Ans 2)
During this state when there is no food for the fifth, the mountaineer has entered the starvation response zone. The level of insulin in the circulation drops and it leads to rise in the level of glucagon, epinephrine and norepinephrine. The glycogen content of the body is consumed and the main source of energy during this phase is derived from triglycerides. The pancreatic cells start to release glucagon as a response to starvation.
Ans ii) The major fuel that is utilized by the skeletal muscles are glucose, fatty acids and ketone bodies. In this the Cori cycle takes place which shifts the overall metabolic burden to the liver. The glycogen that is present is converted into glucose 6 phosphate and while the skeletal muscle contracts, the rate of glycolysis is even more than the rate of citric acid cycle.
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