5. Which gene product interacts with B-catenin? a) ras b) pAPC d) pRb 6. Which g

Question

5. Which gene product interacts with B-catenin? a) ras b) pAPC d) pRb 6. Which gene product, when phosphorylated, directs the transcription of p21? a) ras b) pAPC c) p53 d) pRb 7. Which gene product, when phosphorylated, directs the transcription of BAX? a) ras b) pAPC c) p53 d) pRb 8. Which gene product inhibits E2F transcription factors? a) ras b) pAPC c) p53 d) pRb 9. Which gene product is associated with a rare childhood cancer of the eye? a) ras b) pAPC c) p53 d) pRb 10. Which is NOT a hallmark of cancer? a) cells are insensitive to signals that inhibit growth b) cells acquire limitless replicative potential. c) apoptosis is inhibited. d) cells lose the ability to promote angiogenesis. e) cells acquire the ability to invade other tissues

Explanation / Answer

5. pAPC. Beta-catenin interacts with gene product pAPC.

6. p53. Protein p53 stimulates transcription of the gene encoding a CK1 protein called p21.

7. p53. P53 acts as a transcription factor for numerous genes involved in apoptosis including BAX, PUMA and NOXA.

8. pRb. The active, un or hypophosphorylated form of the pRb protein binds transcription factor E2F1 and represses gene transcription.

9. pRb. Retinoblastoma arises when both copies of RB1 genes are inactivated.

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