36. People who have a genetic deficiency in any of the terminal complement compo

Question

36. People who have a genetic deficiency in any of the terminal complement components (C5,C6. C7, C8, or C9) have increased susceptibility to infections by Neisseria species What is a reasonable conclusion from this observation? a. The MHC Class III recogni ition system is needed to protect terminal complement proteins b. Antibody-mediated opsonization is not effective at mounting an immune response against c the complement cascade does not activate d. the ability of the membrane attack complex to perforate a bacterial cell is an effective from degradation Neisseria sp Neisseria sp first line of defense against Neisseria sp against bacterial pathogens other than

Explanation / Answer

The answer is - d. The ability of the membrane attack complex to perforate a bacterial cell is an effective first line of defense against Neisseria sp.

Since there is only the deficiency of terminal complement components, so complement cascade gets activated and opsonization is also normal, but the formation of membrane attack complex will not take place in absence of C5, C6, C7, C8 or C9, which is very important in the defense again Neisseria sp.

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