looking for the right answers 12. (6 points) Answer parts a-c. The short sequenc

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looking for the right answers

12. (6 points) Answer parts a-c. The short sequence within a protein-coding gene below has great importance and that possible mutations have been identified here in different individuals. You know the effect at the protein level. Indicate ONE possible single- base pair DNA change that could lead to each result. For each patient, write both the wild-type and mutant DNA and protein sequences 5 aat tca tt ccc aag.3 TTA AGT AAA GGG Patient A has a missense mutation. TTC An Phe Pro t ser b) Patient B has a frameshift mutation c) A control, individual C, has a synonymous (silent) mutation.

Explanation / Answer

ANSWER 12.
Wild Type DNA: 5' - AAT TCA TTT CCC AAG - 3'
Protein: NSFPK

Answer a)
Wild Type DNA: 5' - AAT TCA TTT CCC AAG - 3'
Protein: NSFPK
Mutant DNA: 5' - AAT TCA TGT CCC AAG - 3'
Mutant Protein: NSCPK

Answer b)
Wild Type DNA: 5' - AAT TCA TTT CCC AAG - 3'
Protein: NSFPK
Mutant DNA: 5' - AAT TTC ATT TCC CAA G - 3'
Mutant Protein: NFISQ

Answer c)
Wild Type DNA: 5' - AAT TCA TTT CCC AAG - 3'
Protein: NSFPK
Mutant DNA: 5' - AAT TCA TTC CCC AAG - 3'
Mutant Protein: NSFPK

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