6. (20 pts) a) in the mechanism of oxidative phosphorylation, what is the most h

Question

6. (20 pts) a) in the mechanism of oxidative phosphorylation, what is the most highly reduced metabolite involved in the electron flow involved in complexes .,Il, and IV? b) What is the most highly reduced metabolite involved in complexes ll and I c) For complex IV, what is the initial reduced metabolite for electron flow and what is the last reduced metabolite? d) How does the electron flow through complex IlIl contribute to the proton-motive force? e) Is the ATP that is synthesized in oxidative phosphorylation in a eukaryotic cell in the correct cellular location for gluconeogenesis? Why or why not?

Explanation / Answer

a) complex 1 = ubiquinone; complex 3= cytochrome c; complex 4 = oxygen

b) complex 2 = ubiquinone; complex 3 = cytochrome c; complex 4 = oxygen

c)for complex 4 initially reducedmetabolite is cytochrome C which is oxidized by complex IV (cytochrome oxidase). This simultaneously reduces oxygen which is the final reduced metabolite.

d) in complex iii (cytochrome bc complex), a 2 step reaction occurs. In the first step, an electron is transfered from QH2 ( ubiquinol) to cytochrome c releasing 2 protons into the inter membrane space. In the second step, Q accepts electrons from QH and gets reduce which subsequently reduce cytochrome C.

e) yes. Atp is produced in the in the same side as that of gluconeogenesis i.e. In the mitochondria matrix. This would help the direct utilization of ATP in the energy dependant reactions of gluconeogenesis.

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