9 43. Coproporphyrinogen is obtained from uroporphyrinogen by a reactio A. Dehyd

Question

9

43. Coproporphyrinogen is obtained from uroporphyrinogen by a reactio A. Dehydrogenase B. Decarboxylase C. Lyase D. Dehydratase 44. Which of the following enzymes involves in the heme syn he cytosol: thesis is found in t A. ALA synthase B. Coproporphyrinogen oxidase C. Uroporphyrinogen decarboxylase D. Protoporphyrinogen oxidase 45. The two starting materials of the synthesis of the heme are: A. Acetyl Co-A and Glycine B. Propionyl Co-A and Aspartate C. Succinyl Co-A and Glycine D. Succinyl Co-A and Aspartate 46. Hydroxymethylbilane is an intermediate in the heme biosynthesis. Which of the following propositions about it is NOT CORRECT? A. Hydroxymethylbiliane is a linear tetrapyrrole B. Hydroxymethylbiliane undergoes spontaneous cyclization to yield typ uroporphyrinogen catalyzed by uroporphyrinogen III synthase to yield type III uroporphyrinogen porphobilinogen coupled with the removal of four molecules of water C. Hydroxymethylbiliane undergoes in normal conditions an enzymatic cycliz E. All of the above propositions are correct 47. Which of the following porphyrin derivatives is conjugated, reacts directly, and is a ma component of bile? A. Bilirubin diglucuronide B. Stercobilin

Explanation / Answer

43) Decarboxylase

uroporphyrinogen decarboxylase is an enzyme which catalyses the decarboxylation of uroporphyrinogen to coproporphyrinogen

44) Uroporphyrinogen decarboxylase

all the three other enzymes are present in mitochondria

45) Succinyl-coA and Glycine

are the precursors for the synthesis of heme

46) D is a incorrect statement, because 4 molecules of porphobilinogen is required to make hydroxymethylbiliane

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