3. Would you expect to see a difference in the rate of cell division in cancerou

Question

3. Would you expect to see a difference in the rate of cell division in cancerous vs normal breast tissue? What prediction can you make regarding the mitotic index of cancerous breast tissue additional form of cancer-Skin Cancer-used to be seen only in older individuals but is now seen in younger individuals, many in their early 20s. Skin cancer results from aceumulated mutations to the DNA of skin cellis, caused primarily by sun exposure. What factors do you think may be contributing to the increase in skin cancer among young adults? An ad

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Answer 3: Yes. A difference in the rate of cell division is generally noticed for cancerous as compared to normal cells. It is a very well known fact that cancerous cell division and hence DNA replication is highly error prone in nature. This is because the general mechanisms of proof-reading and DNA repair are not performed in cancerous cells. Thus, the cell division beocmes frequent and the mitotic index increases.

As a result, this frequent cellular division in cancerous cells tends to accumulate more mutations due to failure of mismatch repair. Hence, the intensity and severity of cancer cell increases further.

Answer 4: Accumulation of various mutations resulting into development of dermal-cancer generally arise from either mutations or direct exposure to carcinogenes. Long and extended exposures to UV-radiations, sunlight, chemicals, excessive use of potentially carcinogenic cosmetic etc play a critical role in accumulation of these damages. Cumulatively, these potential carcinogens impair the DNA repair mechanism and hence tend to develop cancer, for young adults as well as aged individuals.

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