Write a one-page essay describing how peptide antigens are processed and then bo

Question

Write a one-page essay describing how peptide antigens are processed and then bound to both the MHC-I and MHC-II molecules. Highlight major differences between the two systems MHC classI MHC class ER ytosal antigen veside antigen processing to peptides irn peptide production Nudeus peptide binding by MHC class l peptide transport into endoplasmic reticulum CER) MHC dass I in vesicle peptide binding by MHC dass I MHC class II presents peptide at cell surface MHC dassI presents peptide at cell surface Gelgi CD4 T helper cytotoxic cell binds

Explanation / Answer

MHC class II interacts with CD4+ cells i.e. Thelper cells through endocytic pathway. In this pathway, the foreign particle presented to the helper cells in conjugation with MHCI is derived from endosomes. These peptide come from extracellular microbes or their products that has been endocytosed by APCs and degraded in the acidic environment of the endosomes.processed antigens combine with preassembled class II heterodimers in a special endosomal compartment. This compartment with the class II MHC molecules and the antigen is exocytosed towards the surface and presented to T helper cells/

MHC I class present the peptide antigens to the t cytotoxic cells. The antigen is derived from endogenous proteins of the pathogen that has infected that cell. The processing of endogenous proteins occur in the cytoplasm rather than in acid vesicles. The proteosomes in the cytoplasm break down the protein into peptide fragments. the peptide fragments are transported to the endoplasmic reticulum where they bound to the MHC I

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