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parasite loads, with disseminated cutaneous lesions c) individuals individuals w

ID: 270184 • Letter: P

Question

parasite loads, with disseminated cutaneous lesions c) individuals individuals with a loads, with disseminated cutaneous lesions humoral-dominant response typically have low antibody and low parasite d) individuals with a loads, with localized, self-healing lesions response typically have high antibody and high parasite 21) The endosymbiont Wigglesworthia glossinidia plays a crucial role in immune system function in which parasite vector? a) Sand fly b) Anopheles mosquitos c) Biomphalaria snails d) Tsetse fly anti-VSGa anti-VSGb anti-VSG Type a Type b Type c VSG Time (weeks) Infection The diagram above is referred to in question 22 22) Given the relationship between T. brucei bloodstream parasites and host antibody responses shown above, at which point would the protective mechanism described in the assigned paper (Engstler, et al, Cell 2007) be most helpful to the parasites? a) A b) B c) C d) equally beneficial to the trypanosomes at all three points shown.

Explanation / Answer

21.

Tsetse fly is the correct answer.

22.

Clearance of the antibodies which are surface bound due to new VSG gene allows the parasite to resist for the longer to the immune system. So, all the points are equally beneficial to the trypanosomes at all three points shown.

Hence, the correct option is (d).