With identical dosing intervals and dose levels, a toxicant with shorter half-li

Question

With identical dosing intervals and dose levels, a toxicant with shorter half-life will typically achieve steady state with (an)______ doses as compared to a toxicant with longer half life.
A) more B) Identical number of C) Inverse number of D) fewer With identical dosing intervals and dose levels, a toxicant with shorter half-life will typically achieve steady state with (an)______ doses as compared to a toxicant with longer half life.
A) more B) Identical number of C) Inverse number of D) fewer
A) more B) Identical number of C) Inverse number of D) fewer

Explanation / Answer

When the rate of drug input is equal to the rate of drug elimination, steady state has been achieved.

Ans is (A) more

Because Lower doses and longer intervals will result in lower Css (steady state concentration), while higher doses and shorter intervals will give higher Css values. So when doses of both drug (short half and long half drug) is same then to acheive steady state short half life require more doses to achieve steady state.

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