Can you answer this case study. Thank you. CLINICAL CASE STUDY Invasion from Wit
ID: 270919 • Letter: C
Question
Can you answer this case study. Thank you.CLINICAL CASE STUDY Invasion from Within or Without? A 32-year-old father of two small children lived in the midwestern England on business, he had forgotten his home phone number in United States. An avid hunter since childhood, the man visited annually with family and friends in Colorado for elk hunting. His job required frequent travel to Europe, where he enjoyed exoticfamily was told he had about six weeks to live because there is no foods at his business and had difficulty performing even basic math. In the United States and couldn't remember how to spell his name for directory assistance. By September, his wife insisted he seek medical care. All the standard blood tests came back normal. A psychologist diagnosed depression, but a brain scan revealed spongiform changes. His treatment for this disease. In 1988, his wife recalls, he began having problems. Fre- quently, he forgot to pick up things from the store or even forgot that his wife had called him. Later that year, he was un- able to complete paperwork 1. What is the likely diagnosis? 2. The man's wife wondered, "Can we catch this disease from my husband?" How would you respond? 3. Where and how was the man probably infected? LE 13.5 Comparison of Viruses, Viroids, and Prions to Bacterial Cells Bacteria 200-2000 nm 200-550,000 nm Both DNA and RNA Viruses 10-400 nm 20-800 nm Either DNA or RNA, never 2 nm 40-130 nm RNA only Prions 5 nm 5 nm None Acid?
Explanation / Answer
The person is said to suffer from a variant CJD.
1. Definitive
Diagnosis
Examination of brain tissue is required to confirm a diagnosis of variant CJD. The following confirmatory features should be present.
Numerous widespread kuru-type amyloid plaques surrounded by vacuoles in both the cerebellum and cerebrum – florid plaques.
Spongiform change and extensive prion protein deposition is shown by immunohistochemistry throughout the cerebellum and cerebrum.
Current age or age at death <55 years (a brain autopsy is recommended, however, for all physician-diagnosed CJD cases).
Psychiatric symptoms at illness onset and/or persistent painful sensory symptoms (frank pain and/or dysesthesia).
Dementia, and development ?4 months after illness onset of at least two of the following five neurologic signs: poor coordination, myoclonus, chorea, hyperreflexia, or visual signs. (If persistent painful sensory symptoms exist, ?4 months delay in the development of the neurologic signs is not required).
A normal or an abnormal EEG, but not the diagnostic EEG changes were often seen in classic CJD.
Duration of illness of over 6 months.
2. No, this disease cannot be transmitted.
3. He would be infected in Colorado where he was hunting and enjoying exotic food with his family members.
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