Suppose there is a clinical trial for a combination drug treatment of metformin

Question

Suppose there is a clinical trial for a combination drug treatment of metformin and dichloroacetate for breast cancer treatment. A subject says that as a part of their daily regimen, they take mega-doses of vitamin C. Should this subject be admitted into the linical trial while taking these vitamin C mega-doses? Why or why not? Suppose there is a clinical trial for a combination drug treatment of metformin and dichloroacetate for breast cancer treatment. A subject says that as a part of their daily regimen, they take mega-doses of vitamin C. Should this subject be admitted into the linical trial while taking these vitamin C mega-doses? Why or why not?

Explanation / Answer

This subject should not be admitted into the clinical trial while taking this vitamin C mega-doses, because the vitamin C is itself an antioxidant and can shows an interference with the clinical effects of combination drug treatment of metformin and dichloroacetate and the outcome obtained may be influenced, Hence we have to avoid such individuals participating in the clinical trials.

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