c) The epidermis provides the structural strength of skin. d) Sweat glands origi

Question

c) The epidermis provides the structural strength of skin. d) Sweat glands originate in the epidermis. 26. With regards to allergic contact dermatitis which of the following is true? a) The extent of the response is always dose dependent. b) The extent of the response is generally not dose dependent. c) Allergic contact dermatitis is more common than irritant contact dermatitis. d) Allergic contact dermatitis is usually not associated with erythema (redness) 27. Which of the following is not true regarding the skin a) it is an important route of exposure b) the thickness is not the same over the entire body c) to produce a systemic effect a chemical must reach the dermis d) it is a good barrier to lipophilic compounds 28. Which of the following biological factors affecting percutaneous absorption a) Condition of the skin b) Anatomical site c) Skin age d) All of the above 29. The source of all keratinocytes is the a) stratum basale b) stratum germinativum c) stratum corneum d) stratum spinosum e) stratum granulosunm 30. The toxic effects of chemicals are determined by all of the following except a. The nature of the chemical hazard b. The dose or quantity of the chemical t. The exposure pathway d. The manufacturing process 31. Advantages of in vivo studies include: a. inexpensive b. toxicant effects can be studied under well-controlied conditions c. structural variations between species are minimal d. results depend on self-reporting 32. Any test for toxicity must include the folliowing to be meaningful: a. an appropriate biological model b. well developed protocol c. end point that can be qualitatively and quantitatively assessed d all of the above e. none of the above 33. Which is not an example of a toxicological endpoint? a. necrosis b. inflammation C. ionic bonding d. lipid peroxidation © 2014 Jones & Barett Learning, LLC

Explanation / Answer

Answer:-

26. The correct option is A. Allergic contact dermititis is a dose-dependent phenomenon.

27. The correct option is D. Lipophilic compounds are easily absorbed in the skin.

28. The correct option is D. All of the above.

29. The correct option is A. Stratum basale. It is made up of keratinocyte stem cells thus is the source of keratinocytes in the skin.

30. The correct option is D. Manufacturing process is not important to determine the toxic effect of a chemical.

31. The correct option is C. Structural variations between species are minimal.

32. The correct option is D. All of the above.

33. The correct option is C. Ionic bonding doesn't constitute as toxicological endpoint.

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