9: For kappa light chains the constant (C), joining (J) and variable (V) genes a

Question

9: For kappa light chains the constant (C), joining (J) and variable (V) genes are encoded by different exons. There are 31-36 V genes, 5 J genes, and 1 C gene. The V genes code for the first 95 amino acids in the variable region, the J (joining) region codes for the remaining 13 amino acids of the V region (there are 5 J genes). After joining one V gene to one J gene, they are transcribed. They are ligated with the C gene after splicing a. In the new DNA, if you ligated V6 to J3 and continued through translation, would you still have V7 after all the processes were finished?

Explanation / Answer

a. No, V7 will be absent from the transcript.

Only one V Gene is ligated to one J segment. Then there is transcription of this segment. The other V genes are lost in the process. Only V6 will be transcribed along with J3. V7 will not be transcribed.

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