AND what are TWO additional conclusions you can draw from the data? mRNA process

Question

AND what are TWO additional conclusions you can draw from the data?

mRNA processing and ESCs Wild SON Blue wt Red SON KD 15, type knockdown12 9 Oct4 is an ESC required txn factor Bright field 0 Alkaline phosphatase Alkaline phosphatase is an ESC marker What conclusion do you draw from this figure? A. SON inhibits ESC differentiation and inhibits Oct4 splicing B. SON inhibits ESC differentiation and activates Oct4 splicing C. SON activates ESC differentiation and inhibits Oct4 splicing D. SON activates ESC differentiation and activates Oct4 splicing

Explanation / Answer

What conclusion do you draw from this figure?

B) SON inhibits ESC differentiation and activates Oct4 splicing

1) The spliceosome-associated factor SON as a factor essential for the maintenance of hESCs. Depletion of SON in ESCs results in the loss of pluripotency and cell death.

2) ESC differentiation induced by the downregulation of SON. Depletion of SON resulted in the loss of alkaline phosphatase staining and induced ESC differentiation into fibroblast-like cells.

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