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Uate 39. Signal transduction pathways that require the synthesis of new proteins

ID: 272910 • Letter: U

Question

Uate 39. Signal transduction pathways that require the synthesis of new proteins are g considered fast pathways enerally A. True B. False 40. A synthesized protein with the following configuration will have its N-terminus and C-terminus in which configuration? Signal- protein- stop-protein A. N-terminus ER, C-terminus Cytoplasm B. N-terminus Cytoplasm, C-terminus-ER C. N-terminus ER, C-terminus ER D. N-terminus Cytoplasm, C-terminus- Cytoplasm 41. A scientist has just designed a new drug to treat cancer. She realises that it takes only a few mins for the drug to take effect after binding to its receptor on the cell surface. She correctly concludes that the drug acts by; A. Inhibiting/affecting already synthesized proteins via post-translational modifications B. Increasing DNA activity C. Modifying ribosomal activation D. Reversing the harmful mutagenesis effects that happened to the cel 42. Vesicles that have bound clathrin and adaptin 1 are likely destined to go to which organelle? A Golgi B. Lysosome C. Plasma membrane D. ER 43. Signaling molecules that act on an intracellular receptor are more likely to be; A Large hydrophilic molecules B. Small hydrophobic molecules C. Small hydrophilic molecules D. Large transphobic molecules 44. The final protein responsible for the budding-off of a clathrin-coated vesicle is: A. Dynamin B. Adaptin C. Actin D. Microtubule

Explanation / Answer

39. B

This is because for synthesis of new proteins requires transcription of the gene into mRNA, post transcriptional modifications of the mRNA and then finally translation of the mRNA into functional protein. This is in comparison to signalling pathways involving alterations in already synthesized proteins.

40. D

As the protein consists of even hydrophobic chains, both N- and C-termini will be towards cytoplasm.

41. A

The drug will inhibit the downstream signalling of the receptor by inhibiting the post translational modifications of the proteins like phosphorylation.

42. B

The clathrin coated vesicles fuse with endosomes and then to lysosomes.

43. B

The small hydrophhobic molecules can easily cross the lipid bilayer and bind with their cognate intracellular receptors.

44. A

Dynamin hydrolyzes GTP which leads to the pinching of a completed clathrin coated vesicle.