33. A pro professor creates a drug that inhibits Cat+ release from the sarcoplas

Question

33. A pro professor creates a drug that inhibits Cat+ release from the sarcoplas?m reticul position? psculum, upon administration to the patient, this patient's muscles will be in what A. Normal/unchanged position B. Relaxed position C. Contracted position D. B and C 34. You are studying the effects of a new drug on a cancer cell. You notice that your drug goes into the cytoplasm and inhibits a growth signal that is secreted by the tumor. This drug must work by A. Blocking an intracellular receptor B. Blocking an extracellular receptor C. Activating a kinase D. Enhancing an intracellular cascade 35. In order to enter the mitochondria, proteins need to be unfolded A. True B. False

Explanation / Answer

33. B

Ca2+ release from sarcoplasmic reticulum is required for the contraction of muscles. So blocking this release prevents muscle contraction and keeps the muscle in relaxed state.

34. A

The drug will bind the receptor and prevent it's interaction with the growth signal. As a result of this the signalling cascade will be inhibited.

35. A

Proteins destined for mitochondria are maintained in an unfolded state by cytoplasmic chaperones. The proteins are then imported into mitochondria by two translocation complexes TOM and TIM. Once inside the mitochondrial matrix, the proteins are then folded into their final native conformation.

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