y another user. Save As Case 1 J.F. is a 26-year-old woman in the clinic today f
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y another user. Save As Case 1 J.F. is a 26-year-old woman in the clinic today for her annual physical examination. As you take her medical history, it becomes apparent that she is quite concerned about her risk for developing breast cancer. Her mother and a maternal aunt both developed breast cancer in their late 40s. J.F. has heard that genetic testing can be done to see whether she carries "breast cancer genes." Discussion Questions . Assuming J.F. is talking about the BRCAI and BRCA2 genes, explain the role that these genes have in the genetic mechanisms of breast cancer. 2. If genetic testing reveals that J.F. does carry the BRCA1 gene, what does this mean 3. What proportion of breast cancer cases can be attributed to inherited forms? 4. What other cancer would J.F. be at risk for given the presence of the BRCAI gene? 5. What other risk factors should be investigated to evaluate J.F.'s risk for breast for her risk of developing breast cancer? How significant is that risk? cancer? (Go to the discussion of breast cancer in your text, Chapter 33) DOLL F11 F12 F8 F9 F6 F10 F4 F5 9Explanation / Answer
1)
BRCA 1 & 2 are DNA repair genes which synthesize proteins that repair Double stranded breaks or destroy cells if repair is not possible. These genes are present in humans normally but a mutation can render them non-functional and thereby exposing the person to high risk of cancer.
2)
If the testing reveals them to possess mutation in these genes then it means there rendered susceptible to errors in DNA and thus develop cancer.
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