13. A polyclonal antiserum raised against pooled human IgA will react with A) hu
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13. A polyclonal antiserum raised against pooled human IgA will react with A) human IgE B) human IgG. c) J chain. D) human IgM. 14. M ucosal epithelia of the gastrointestinal tract, eyes, nose, throat, the respiratory, urinary, and genital tracts, and the mammary glands are protected by A) IgE B) dimeric IgA C) IgG D) monomeric IgA 15. The relative level of specific IgM antibodies can be of diagnostic significance because viral infection often results in very high IgM responses. A) #8) relatively high levels of IgM often correlate with a first recent exposure to the ind ucing agent. e) IgM is easier to detect than the other isotypes D) IgM antibod ies are more often protective against reinfections than are the other isotypes. Which of the following is the major function of the lymphoid system? A) phagocytosis. B) acquired immunity. C) inflammation. 16. D) innate immunity. Professional APC that present any antigen indiscriminately to T cells are A) Dendritic cells, macrophages, and B lymphocytes. B) Dendritic cells and macrophages c) Dendritic cells, macrophages, and neutrophils. D) Follicular dendritic cells, macrophages, and B lymphocytes. 17. 18. In order for a B cell to receive T cell help, the B cell must A) Present peptides via MHC II. B) Present peptides via MHC I. c) Secrete TNF and IL-2 D) Express CD28. 19. The following properties of human lgG are true except: A) It induces the formation of leukocytes. B) Its half-life is approximately 23 days. c) It can pass through the placenta. D) It can be cleaved by pepsin and yet remain divalent. Page 3Explanation / Answer
13) Answer ABCD
Antibody to IgA will have antibody specific for kappa and lambda light chains, will react with IgG and IgM, both of which have k and l chains. Antibody will also be present against J chain if the IgA used for immunization was dimeric.( IgM has the J chain and all Ig have ? adn ? chains.)
14) Answer B: dimeric IgA.
15) Answer B: relatively high levels of IgM often correlate with a first recent exposure to the inducing agent.
16) Answer B: acquired immunity
The major function of the lymphoid system is the recognition of foreign antigen by lymphocytes, which leads to the acquired immune response. Functions such as phagocytosis and inflammation do not necessarily require the lymphoid system, and they constitute part of innate immunity.
17) Answer A
Professional antigen-presenting cells , include the macrophages, B cells and dendritic cells.
19) Answer A
Human IgG is the only Ig that passes across the placenta. It has a half-life of 23 days, It can be cleaved by pepsin to yield a divalent antibody portion. It does not induce the formation of leukocytes
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