the second picture is for question #5 if you can\'t see the first one. thanks HO
ID: 274713 • Letter: T
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the second picture is for question #5 if you can't see the first one. thanks
HO Question 5 uses the multipotent hemopoietic stem cell image on the right. 5. a. Identify which cell is the self-renewing stem cell. 5b. Identify which cells are proliferating precursor cells Sc. Identify which cells are terminally differentiated cells bsepht CO GON 6. Cancer is excessive cell proliferation and survival. DNA damage is responsible for cancer and when the cell senses DNA, the cell cycle should be inhibited until the damage is fixed. If the DNA repair mechanisms are not working, why does this result in the production of cancer cells that have a competitive advantage over normal cells?Explanation / Answer
5(a) Hematopoietic stem cell have tha capacity to differentiate into many other cell type and also property of self -renewal .HSCs cell maintain their appropriate no. In the bone marrow .
(B) Precursor proliferating cells are the B-lymphoctes,T-lymohocytes and monocyte are responsive cells that produces antibodies and T(helper and cytotixix cells ) are produced.
(c)Cells such as eosinophils,neutrophils ,macrophages etc. are the terminally differentiated cells which are differentiated.They interacts with pathogen directly.
6. DNA damage is responsible for the cancer production due to the loss of function of tumour suppressor genes like the p53 ,and the gain of function mutation in proto-oncogenes.DNA damage is checked by ATM and ATR proteins.If they are defect in DNA damage or Mutation
It will cause conversion of proto oncogenes into the oncogenes and ultimately cancer .Many type of cancers arises due to the defective DNA damage repair in the body.
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