Some chemicals, such as DNP, create pores in the mitochondrial membrane that let

Question

Some chemicals, such as DNP, create pores in the mitochondrial membrane that let protons leak through. What would happen in a cell with DNP poisoning? Select all that apply O The electrons won't be transferred to oxygen, thus, there will be no movement of electrons Electrons from electron carriers, such as NADH and FADH2 cannot be accepted anymore. O NADH and FADH2 won't be oxidized back into NAD+ and FADH, and will accumulate. 3 Protons moved into the intermembrane space will quickly diffuse back into the mitochondrial matrix disrupting the proton gradient. D ATP production will drop substantially

Explanation / Answer

The correct options are:

Protons moved into the intermembrane space will quickly diffuse back into the mitochondrial matrix disrupting the proton gradient.

ATP production will drop substantially.

DNP is an uncoupling agent.Uncoupling agents uncouple oxidation from phosphorylation. They allow the oxidation of NADH and FADH2 and reduction of O2 to continue at higher levels but do not permit ATP synthesis. DNP dissipates proton gradient and inhibits ATP synthesis.

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