. T-Mobile LTE 1:08 PM Cancel 1. (15 pts total Mutation of a tumor suppressor ge
ID: 274890 • Letter: #
Question
. T-Mobile LTE 1:08 PM Cancel 1. (15 pts total Mutation of a tumor suppressor gene, APC, is for hereditary colorectal cancer. Being a responsible Gastrointestinal specialist, you routinely check whether patients' APC gene is mutated. Patient A: has gain of function mutation of APC. Patient B: has loss of function mutation of APC. Patient C: has no mutation of APC, but GSK3-beta is non- functional a) Predict the outcomes such as" high risk", “low risk" or "modest risk" for cancer in each patient based on the information provided above (1 pt each) b) In addition to your prediction, explain to the patient the and others are low risk for cancer (4 pts for each patient) 2. You took a job in a small town teaching in a university molecular mechanism of why some of them are high risk After several months, you have noticed a very high percentage of liver cancer incidence around the neighbors you talked to. What information (survey, test) will you need to find out whether it is hereditary or environmental factors? (10 pts) 3 To treat cancer effectively, many factors need to be considered: doubling time, percent of cells are dividing, and so on. Using the information in our lecture, predict and explain the success rate of chemotherapy for a) lung cancer and b)lymphoma based on those factors. (5 pts each) 4. You observed the increase in cyclin gene expression in samples from cancer cells, compared to the non-dividing normal cells. Briefly describe how to use microarray chip to find altered gene expressions that are linked to cancer (5 pts). In addition, design experiments to find out function of those genes in tumorigenesis (7 pts).Explanation / Answer
1) APC is a tumor suppressor gene which controls the cell division. Patient A is at low risk for cancer development
Patient B is at high risk due to loss of function of APC
patient C is at moderate risk
APC helps regulate many proteins that in turn regulate the cell division. One such protein is Beta catenin and is involved in wnt Pathway. Beta catenin increases cell division and is regulated negatively by APC
2. APC mutation marks inherited mutation
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.