Silicosis is a debilitating miner\'s disease that results from the ingestion of

Question

Silicosis is a debilitating miner's disease that results from the ingestion of silica particles (such as sand or glass) by macrophages in the lungs. Asbestosis is a similarly serious disease caused by inhalation of asbestos fibers. In both cases, the particles or fibers are found in lysosomes, and fibroblasts, which secrete collagen, are stimulated to deposit nodules of collagen fibers in the lungs, leading to reduced lung capacity, impaired breathing, and eventually death. Part E How can cell death continue almost indefinitely, even after prevention of further exposure to silica dust or asbestos fibers? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not all terms will be used. Reset Help damage release not digestible digestible particles Because the fibers and are and there is no mechanism to remove them from the a cycle of uptake, lysosomal death, and fiber or particle is set up that can continue indefinitely, killing more and more cells. cell lungs Submit Request Answer

Explanation / Answer

Because the fibers and particles are not digestible and there is no mechanism to remove from the lungs, a cycle of uptake, lysosomal damage, cell death, and fiber or particle release is set up that can continue indefinitely, killing more and more cells.

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