1701/162.101 MANIALB Internal CP ASR TR NSB Sc For Questions 12 and 13 use the m

Question

1701/162.101 MANIALB Internal CP ASR TR NSB Sc For Questions 12 and 13 use the mRNA codon key GCC Alanine, AAU Asparagine, CCU Proline, GGA Glycine, UGG Tryptophan, UGA "Stop" (no amino acid) GAA Glutamic acid, GAG Glutamic acid, AGG Arginine. CCC Proline, CAU Histidine. The following DNA sequence (coding, or non-template strand) occurs near the middle of the coding region of a gene, commencing at nucleotide 45: 45 50 60 65 5._ A A T G A A T G G G A G C C T G A A G G A G-3. When the corresponding mRNA is made by transcription, the first triplet of nucleotides AAU (underlined) is in frame for coding, and encodes Asparagine. 12) Which of the following DNA mutations is almost certain to result in a shorter than normal mRNA? B) G?A at position 53 D) A- G at position 61 A G at position 50 C A at position 58 E) None of the above Which of the following DNA mutations is almost certain to result in a shorter than normal protein? A) T-C at position 59 B) A- G at position 61 CInsertion of a G after the G at position 54 D) C- A at position 58 E) None of the above 13)

Explanation / Answer

Ans12:

(E) none of the above

Note: mutations in dna may only change the sequence of mRNA--- but not the length . Thus, none of these mutations can lead to shorter mRNA.

Ans 13:

(E) none of the above

Note: A mutation can result into shorter Protein only if leads to generation of a stop codon ( UAA/UAG/UGA). But none of the mentioned mutations (a to d) can form stop codons.

Also note that UAA/UAG/UGA of mRNA--- is read as TAA/TAG/TGA in the coding or non template strand.

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