5. The insulin receptor substrate 1 (IRS) assists in reactivation of the insulin
ID: 275412 • Letter: 5
Question
5. The insulin receptor substrate 1 (IRS) assists in reactivation of the insulin receptor by __________ of PTP1B, which in turn _________ the insulin receptor.
phosphorylation; phosphorylates
dephosphorylation; dephosphorylates
phosphorylation; dephosphorylates
dephosphorylation; phosphorylates
8. A comparison of the insulin signaling pathway in Homo sapiens, Alligator mississppiensis, and Falco cherrug indicates that this pathway is _____ conserved, with the exception of factors associated with ________ in the American alligator.
highly; antiapoptosis
not highly; antiapoptosis
highly; apoptosis
not highly; apoptosis
10. Which protein factor is found in the nucleus?
Ste2
Ste5
Ste7
Ste12
Explanation / Answer
5) Answer : phosphorylation; phosphorylates
PTP1B (protein tyrosine phosphatase) is a negative regulator for insuling signalling pathway. Therefore, dephosphorylation of PTP1B can dephosphorylate insulin receptor and inactivate it.
10) Answer : Ste12
Ste5 : It acts as adapter and scaffold as it has no catalytic activity and it is the second effector for G? subunit, MAPK cascade kinases. It is found predominantly in the nucleus or shuttles between cytoplasm and nucleus.
Ste12 : It is found in nucleus as it is a DNA-binding transcriptional transactivatorRelated Questions
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