The human D1S80 locus is highly polymorphic, with many possible variants found i

Question

The human D1S80 locus is highly polymorphic, with many possible variants found in any given population. Based on the allele frequencies given on your lab manual, calculate the probability that a person of Japanese descent would be homozygous for allele #29.

_____%

Now, calculate the probability that a person of African-American descent would be homozygous for that same allele.

______%

D1S80 Allele Frequencies (n- number of alleles typed) U.S. Caucasian African-American U. S. Hispanic Japanese 13 0.003 0.003 0.013 0.263 0.005 0.020 0.025 0.028 0.003 0.318 0.055 0.010 0.008 0.050 0.055 0.055 0.058 0.003 15 16 17 18 19 0.045 0.006 0.146 0.017 0.238 0.010 0.040 0.018 0.030 0.008 0.348 0.040 0.015 0.013 0.063 0.053 0.008 0.080 0.013 0.003 0.003 0.003 0.005 0.008 0.048 0.098 0.003 0.033 0.115 0.088 0.023 0.193 0.023 0.008 0.013 0.153 0.055 0.008 0.048 0.005 0.005 0.073 0.017 0.022 0.219 0.011 0.006 0.034 0.090 0.051 0.146 0.124 23 24 25 27 28 31 0.017 0.011 0.008 34 35 0.003 0.003 0.005 0.010 0.005 37 0.017 0.003 0.003 40 41 0.006 0.017 0.005 0.010

Explanation / Answer

DS180 allele frequencies in Japanese population= 0.146

Number of DS180 alleles mapped= 0.146*178= 26

To have a homozygous individual, the probability becomes= frequency of DS180 in 1 allele*frequency of DS180 allele in 2nd allele.

=0.146*0.146=0.021= 2.1 of the japanese population are homozygous for DS180 allele.

Similarly for African American descent probability for the gene to be homozygoud=0.008*0.008=0.0064= 0.64 % of total African American population that could be homozygous for DS180 allele.

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