16-38 The growth factor RGF stimulates proliferation of cultured rat cells. The

Question

16-38 The growth factor RGF stimulates proliferation of cultured rat cells. The receptor that binds RGF is a receptor tyrosine kinase called RGFR. Which of the following types of alteration to RGF would be most likely to prevent receptor dimerization? (a) a mutation that increases the affinity of RGFR for RGF (b) a mutation that prevents RGFR from binding to RGF (c) changing the tyrosines that are normally phosphorylated on RGFR dimerization to alanines changing the tyrosines that are normally phosphorylated on RGFR dimerization to glutamic acid (d)

Explanation / Answer

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Q. The growth factor RGF stimulate proliferation of cultured rat cells. The receptor that binds RGF is receptor tyrosine kinase called RGFR. Which of the following types of alteration to RGF would be most likely to prevent receptor dimerization?

Answer: Option B (a mutation that prevents RGFR from binding to RGF)

Explanation: As we know that the RGF is responsible for the proliferation in rat cells and this proliferation is initiated when the receptor (RGFR) is bind to the RGF. If we cause any mutation in the cell which prevents the binding of the growth factor RGF to the receptor RGFR then there will be no receptor dimerization took place which further stops the cell proliferation in rat cells.

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