Learning objectives for this problem are to: Model how enzyme activities can shi

Question

Learning objectives for this problem are to: Model how enzyme activities can shift the state of chromatin in the genome. Use critical thinking and hypothesize how epigenetic mechanisms can cause cancer. euchromatin heterochromatin Me Me, ON Acetylated Histones OFF Methylated cytosine It was discovered that a patient with lung cancer was found to respond well to a new class of drug called DNA methyl transferase inhibitors (DNA methyl transferase is an enzyme that can add methyl groups to the cytosine bases in DNA). Question: A revolutionary genome editing tool, CRISPR, is now becoming useful to correct DNA sequences in the genome. Assuming this is a reliable method, would you recommend that this patient use CRISPR to correct his gene? Explain your reasoning.

Explanation / Answer

Epigenetics, is the change in the gene expression, as a result of changes in the structure of chromosome. This does not involves changes in the nucleotide sequence, but involve bases and histone modifications. whereas CRISPR-Cas 9 is used to knock out a mutated gene and does not alters epigenetic changes associated with a gene.

hence, CRISPR-Cas 9 cannot be used to cannot be used to correct this gene.

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