5. You have run across a family in which several members have developed colon ca

Question

5. You have run across a family in which several members have developed colon cancer in the 30-50 age range. You check all the known genes involved in hereditary colon cancer and find no suspicious mutations among them. You manage to piece together the health history of a number of generations in the past shown to the right. You are convinced that it is hereditary, and therefore may involve a novel gene involved in cancer You have access to the couple in the last generation of the pedigree above and their five children and three young grandchildren. Their pedigree is continued below. Man II has undergone surgery and chemotherapy and is ok for the moment, as is the case for his affected daughter. His older son's cancer was caught too late. After looking for linkage between the cancer and an assortment of markers you determine that a particular microsatellite marker seems to be linked to the disease. Below is the recent family pedigree with electrophoretic analysis of the microsatellite for each individual shown under each individual. a) How does the disease appear to be inheriting? b) Which individuals are likely to get colon cancer by the age of 50? c Not all of the microsatellite results are as expected. Which ones are not, and give two different reasonable reasons why the bands are the way they are

Explanation / Answer

The family member may have adenomatous polyps gland which are gland like growths that develop eventually on the mucous membrane that lines or cover the large intestine. Which may be the cause of colon cancer?
If mutated (abnormal) type of KRAS gene are not involved here,

If children from generation II the affected son and daughter marry their children might have the diseased condition or if adenomatous polyps gland develop in any of the member in generation II and III they will get it by age of 50
The second lane is not as expected since, the father is diseased the son should have it also may be since it is not a case of genetic mutation.

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