Problem II. Seven different recessive point mutations (1-7) that cause uncoordin

Question

Problem II. Seven different recessive point mutations (1-7) that cause uncoordinated movement in C. elegans were isolated. The table below shows the F, mutation were crossed to perform phenotypes that resulted when strains (numbered 1-7) homozygous for each complementation tests; "u', indicates uncoordinated and “+" indicates normal. tests; 5 2 1) Based on these results, how many different GENES are affected by these seven mutations? Answer 2) How many of the genes (from the previous answer) are represented by ONLY 1 of the seven mutant alleles? Which mutation(s) affect(s) this/these gene(s)? # of genes with one mutation- Mutation(s) that affect this/'these gene(s)fenter any all strain #'s that apply

Explanation / Answer

When two mutants are crossed and the resultant F1 progeny shows WT phenotype, it means that both the mutations are located in different genes. i.e. they are non-allelic.

When two mutants are crossed and the resultant F1 progeny shows mutant phenotype, it means that both the mutations are located in the same gene. i.e. they are allelic to each other.

'+' means WT phenotype

'u' means mutant phenotype

From the given table,

Complementation groups:

i. 1 = 5

ii. 2 = 6

iii. 3 = 4

iv. 7

Number of different genes = 4

Only mutant 7 is represented by a single allele. Remaining all mutants have two alleles.

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