M. Mallo et al. / nvelopnentd Bhol ?344 (2010) 7-15 T13 A13 Hoxb Sacral 81 ???--

Question

M. Mallo et al. / nvelopnentd Bhol ?344 (2010) 7-15 T13 A13 Hoxb Sacral 81 ???--?????? Hox 12 CIJ HoxD- Control T13 T1 Control Hox10GOF Hox10LOF Hox6LOF OF Hox6GOF gional paneming of the axial skeleton by Hox paralogpns groupse and 10. f genes in the para g Ho go ups 6 (red labels) and 10 (gre enlabels) Ha C10Pnes havenb blocking activity as sho n by showing the effiects of glotul inctivation (LOF) or of edopk w inactivation of this paralog group (D) and by the compinte abnnce of ribs (green asterisk) after precocous activation of Hoxa 10 in the presonitic me PC6 genes are able to induce ectopic ribs at aervical(K' in P) and lumbar (G) levels. Complese inxctivation of trib in this specimen is attached to the second thoracic vertebra T2), indicating that other genes must also cooperate in the rnit-inducing p HonGs os (E) results in smaller ib cages and lossof ocess A schematic repres the first thoracic (TI), las n for selrena, Seletions of wild tye embayos are shown in A and t. The lumibar and sacal donulns the pouon o the fhist fioTE ONC mteridisl ertehrae are indicated or

Explanation / Answer

Hox paralogous group genes have specific roles in the axial patterning. These genes control the morphological features along regions of the vertebral column. So the activation and inactivation of these genes have an effect on the axial skeletal patterning. The Hox6 is indicated by red colour and the expression of Hox6 ectopically resulting in GOF shows ribs at cervical and lumbar levels and inactivation resulted in smaller rib cages and specific ribs are lost. So by the above phenotypes the role of Hox6 gene is to induce rib morphogenesis this promotes the expression in somites(each number of body segments) those generating the thoracic region. So Hox6 to induce the rib formation involves the stimulation of non-myogenic activity in the myogenic(originating in muscle tissue) genes they are Myf5 and Myf6 genes in the myotome(group of muscles) Then the myotome instructs the sclerotome(part of each somite in a vertebrate embryo which gives rise to skeletal tissues) So in this way Hox6 gene plays an important role in axial skeletal patterning.

Hox10 role is just negative to Hox6 gene. This blocks the expression in somites adjacent to hindlimb. It plays a role in rib blocking and inhibits the rib formation. So in Hox6 it involves stimulation of Myf5 and Myf6 but Hox10 genes prevents the stimulation of these genes and thereby it results in inhibting the formation of ribs.

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