Joe Contelo, a 5th year graduate student, is trying to develop an antibody based

Question

Joe Contelo, a 5th year graduate student, is trying to develop an antibody based vaccine. He is ready to use a mouse model to test the magnitude and duration of the antibody production after antigen administration. Which of the following experimental approaches would you recommend? Select one: a. Inject antigen and draw blood after 2 days for further testing of antibody levels. ? b. Inject the antibodies and draw blood after 2 weeks to test the antigen c. Inject antigen twice with about 3 weeks in-between, then measure antibodies in serum after additional 8 weeks d. Inject antigen and take out the regional lymph nodes after 1 week and look for plasma cells. e. Inject antigen and determine serum IgM after 1 week

Explanation / Answer

Option "C" is correct.

For antibody production in mouse model, antigen is administered twice: first injection (day 1) to generate immune response against the antigen, booster injections (day 14 and day 28) to produce large quantity of antibodies (by plasma B cell). Test the bleeds and perform antibody titration (day 42 to day 60).

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