13. The concentration of mitotic cyclin: A. rises dramatically during M phase. B

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13. The concentration of mitotic cyclin: A. rises dramatically during M phase. B. changes as Cdk concentration changes. C. falls during M phase due to its destruction. D. is highest in G1 phase. E. determines the timing of mitosis in the cell cycle 14. Disassembly of the nuclear envelope: A. occurs during prophase. B. involves the separation of the inner nuclear membrane from the outer nuclear membrane. results in the conversion of the nuclear envelope into protein-free membrane vesicles. is triggered by the phosphorylation of integrins. C. D. E. must occur in order for kinetochore microtubules to form. 15. The tryptophan (trp) operon of E. coll is repressed by tryptophan aded to the growth medium. The 15. T tryptophan repressor probably: A. binds to RNA polymerase when tryptophan is present. B. binds to the trp operator in the absence of tryptophan. C. binds to the trp operator in the presence of tryptophan. D. is a DNA sequence. 16. A mutant yeast strain stops growing and dividing when shifted from 25°C to 37°C. When this strain is yzed, at either 25°C or 37°C, using a machine that sorts cells according to the amount of DNA they contain, the following graphs are obtained. Which of the following would explain the behavior of your mutant? A. B. C. D. E. Inability to initiate DNA replication Defect in chromosome condensation Defect in centrosome duplication Defect in cytokinesis Inappropriate production of a signal that causes cells to remain in Gl. amount of ONAeell tarbitrary snits) 37°C amount of DNAlell (arbltrary unital

Explanation / Answer

13.falls during M phase due to its destruction

14.must occur in order for kinetochore microtubules to form

15.binds to the trp operator in the presence of tryptophan

16.defect in chromosome condensation i.e. inability to begin M phase

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