1. (2 points) You are doing FISH using cells from a living male who had slow gro
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1. (2 points) You are doing FISH using cells from a living male who had slow growth rate before birth, low birth weight, heart defects, small jaw and head and overlapping fingers. Although the child is still too young to exhibit learning difficulties, you suspect this symptom will appear. You suspect the individual has Edward's syndrome (Trisomy 18). You choose to use FISH as a method to confirm this diagnosis before informing his parents. Please answer the questions below. a. (1 point) To which chromosome would you design the probe to test whether this newborn has trisomy 18? ANS: b. (0.5 points) If this newborn has trisomy 18, how many spots would you see after performing FISH? ANS: c. (0.5 points) if this newborn does not have trisomy 18, how many spots would you see after performing FISH? ANS: ) You need to also have a control probe. You choose to use a probe to the X- d. (1 points chromosome as your control ANS: I. How many spots would you see for this newborn?Explanation / Answer
a. For determining the trisomy of chromosome 18 will have to design the probe for the chromosome 18.
b. if the newborn has trisomy for the chromosome 18 then there would be three spots after performing the FISH test.
c. if the newborn does not have trisomy for the chromosome 18 then the normal 2 spots will be appeared after the FISH test.
d. only one spot will be appear for this new born.
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