You are studying the psychopharmacological effects of lithium. Your literature s

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You are studying the psychopharmacological effects of lithium. Your literature searches indicate that, in the neuron, Li+ interferes with the metabolism of the secondary messengers polyphosphoinositide and inositol via uncompetitive inhibition of the enzyme inositol monophosphatase (Nahorski et al. (1991) Trends Pharamacol Sci 12:297-303). What is the action of the lithium on the target enzyme?

You are studying the psychopharmacological effects of lithium. Your literature searches indicate that, in the neuron, Li* interferes with the metabolism of the secondary messengers polyphosphoinositide and inositol via uncompetitive inhibition of the enzyme inositol monophosphatase (Nahorski et al. (1991) Trends Pharmacol Sci 12:297-303). What is the action of lithium on the target enzyme? A. t competes with phosphate for the active site B. It binds the enzyme in a region other than the active site C. It only binds to the enzyme-substrate complex D. It only binds to the free enzyme E. None of the above

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What is the action of lithium on the target enzyme?

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