In newly formed neural tube, the intermediate region close to the sulcus limitan
ID: 282619 • Letter: I
Question
In newly formed neural tube, the intermediate region close to the sulcus limitans has been not exposed to molecules that induce ventral or dorsal characteristics. You perform explant experiments in which you take intermediate neural tube (host tissue) and culture them with donor tissue explants that induce specific spinal cord markers in the host explant.
The induced host tissue expresses Shh following transplant.
A. What donor tissue have you explanted next to the host tissue, what signal is released to induce this marker, and what cell type has been induced? Briefly explain your reasoning.
Explanation / Answer
A.We have implanted notochord tissue next to the host tissue.The notochord tissue expresses Shh gene that acts as a morphogen to induce specific spinal cord markers in the host explant. The cell type that has been induced are the progenitor neural cells.Shh acts as a long-range morphogen that funtions to direct the pattern of neurogenesis as it passes positional information to the progenitor neural cells for formation of spinal cord.
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